:root {
  color-scheme: dark;
  --ink: #070b1c;
  --ink-raised: #0d1430;
  --ink-soft: #121d3d;
  --cobalt: #2f6bff;
  --cobalt-soft: #8aaaff;
  --foam: #dbe5f7;
  --foam-muted: #aebdd5;
  --line: rgba(47, 107, 255, 0.48);
  --line-soft: rgba(219, 229, 247, 0.15);
  --good: #9ec2ff;
  --max: 72rem;
  --measure: 68ch;
  --space-1: 0.5rem;
  --space-2: 0.875rem;
  --space-3: 1.25rem;
  --space-4: 2rem;
  --space-5: 3.5rem;
  --space-6: 6rem;
  --border: 1px solid var(--line-soft);
  --focus: 3px solid var(--foam);
}

* {
  box-sizing: border-box;
}

html {
  background: var(--ink);
  color: var(--foam);
  font-family: Georgia, "Times New Roman", Times, serif;
  font-size: 18px;
  line-height: 1.65;
  scroll-behavior: smooth;
}

body {
  margin: 0;
  min-width: 0;
  overflow-x: hidden;
  background:
    radial-gradient(circle at 14% 5%, rgba(47, 107, 255, 0.13) 0 2px, transparent 3px),
    radial-gradient(circle at 87% 16%, rgba(47, 107, 255, 0.18) 0 2px, transparent 3px),
    var(--ink);
}

a {
  color: var(--foam);
  text-decoration-color: var(--cobalt);
  text-decoration-thickness: 0.12em;
  text-underline-offset: 0.2em;
}

a:hover {
  color: #ffffff;
  text-decoration-color: var(--cobalt-soft);
}

a:focus-visible,
button:focus-visible,
input:focus-visible {
  outline: var(--focus);
  outline-offset: 4px;
}

p,
dd,
label,
button,
figcaption,
footer a,
footer p {
  font-size: 1rem;
}

p,
dd {
  max-width: var(--measure);
}

h1,
h2,
h3 {
  color: #ffffff;
  font-weight: 600;
  line-height: 1.08;
  text-wrap: balance;
}

h1 {
  max-width: 17ch;
  margin: 0 0 var(--space-3);
  font-size: clamp(2.45rem, 7vw, 5.8rem);
  letter-spacing: -0.045em;
}

h2 {
  max-width: 26ch;
  margin: 0 0 var(--space-3);
  font-size: clamp(1.75rem, 4vw, 3rem);
  letter-spacing: -0.025em;
}

h3 {
  margin: 0 0 var(--space-1);
  font-size: 1.2rem;
}

header,
main,
footer {
  width: min(100% - 2rem, var(--max));
  margin-inline: auto;
}

header {
  display: flex;
  min-height: 5rem;
  align-items: center;
  border-bottom: var(--border);
}

header a {
  display: inline-flex;
  min-height: 44px;
  max-width: 100%;
  align-items: center;
  font-family: ui-monospace, SFMono-Regular, Menlo, Consolas, monospace;
  font-size: 0.9rem;
  letter-spacing: 0.02em;
  line-height: 1.35;
  overflow-wrap: anywhere;
  text-decoration: none;
}

main {
  padding-block: var(--space-5) var(--space-6);
}

main > section,
main > aside,
main > figure {
  margin-top: var(--space-6);
}

main > section:first-child {
  margin-top: 0;
}

[data-kicker] {
  display: inline-flex;
  min-height: 44px;
  align-items: center;
  margin: 0 0 var(--space-2);
  color: var(--cobalt-soft);
  font-family: ui-monospace, SFMono-Regular, Menlo, Consolas, monospace;
  font-size: 0.85rem;
  letter-spacing: 0.09em;
  text-transform: uppercase;
}

[data-lede] {
  max-width: 56ch;
  margin: 0;
  color: var(--foam);
  font-size: clamp(1.16rem, 2.3vw, 1.45rem);
  line-height: 1.5;
}

[data-note] {
  max-width: var(--measure);
  padding: var(--space-3);
  border-left: 4px solid var(--cobalt);
  background: var(--ink-raised);
  color: var(--foam);
}

[data-grid] {
  display: grid;
  grid-template-columns: repeat(12, minmax(0, 1fr));
  gap: var(--space-3);
}

[data-grid] > article,
[data-grid] > section {
  grid-column: span 6;
  min-width: 0;
  padding: clamp(1.25rem, 3vw, 2rem);
  border: var(--border);
  border-top: 3px solid var(--cobalt);
  background: var(--ink-raised);
}

[data-grid="three"] > article {
  grid-column: span 4;
}

article p:last-child,
section p:last-child {
  margin-bottom: 0;
}

[data-route] {
  display: grid;
  grid-template-columns: repeat(5, minmax(0, 1fr));
  gap: 1.75rem;
  position: relative;
  margin-block: var(--space-5);
  padding: var(--space-4) 0;
}

[data-route]::before {
  content: "";
  position: absolute;
  top: 50%;
  right: 5%;
  left: 5%;
  height: 2px;
  background: var(--cobalt);
  transform: translateY(-50%);
}

[data-route] span {
  display: grid;
  z-index: 1;
  min-height: 7.5rem;
  place-items: center;
  padding: var(--space-2);
  border: 2px solid var(--cobalt);
  border-radius: 50%;
  background: var(--ink-raised);
  color: #ffffff;
  text-align: center;
}

[data-network] {
  display: grid;
  grid-template-columns: repeat(3, minmax(0, 1fr));
  gap: var(--space-4);
  position: relative;
  min-height: 20rem;
  margin-block: var(--space-5);
  padding: var(--space-4);
  border: var(--border);
  background: var(--ink-raised);
}

[data-network]::before,
[data-network]::after {
  content: "";
  position: absolute;
  height: 2px;
  background: var(--cobalt);
  transform-origin: left center;
}

[data-network]::before {
  top: 30%;
  left: 18%;
  width: 65%;
  transform: rotate(12deg);
}

[data-network]::after {
  top: 69%;
  left: 13%;
  width: 69%;
  transform: rotate(-10deg);
}

[data-node] {
  display: grid;
  z-index: 1;
  min-height: 6.4rem;
  place-items: center;
  align-self: center;
  padding: var(--space-2);
  border: 2px solid var(--cobalt);
  background: var(--ink);
  text-align: center;
}

[data-node]:nth-child(2),
[data-node]:nth-child(5) {
  transform: translateY(2.5rem);
}

[data-node]:nth-child(3) {
  transform: translateY(-1.5rem);
}

[data-bars] {
  max-width: 46rem;
  padding: var(--space-4);
  border: var(--border);
  background: var(--ink-raised);
}

[data-bar] {
  display: grid;
  grid-template-columns: minmax(7rem, 11rem) 1fr auto;
  gap: var(--space-2);
  align-items: center;
  margin: var(--space-3) 0;
}

[data-bar] i {
  display: block;
  height: 1.25rem;
  background: var(--cobalt);
}

[data-bar="trial-treatment"] i { width: 75%; }
[data-bar="trial-placebo"] i { width: 12%; }
[data-bar="nausea-treatment"] i { width: 88%; }
[data-bar="nausea-placebo"] i { width: 32%; }

[data-bars] figcaption {
  margin-top: var(--space-3);
  color: var(--foam-muted);
}

dl {
  display: grid;
  grid-template-columns: minmax(10rem, 0.7fr) minmax(0, 1.8fr);
  gap: 0;
  max-width: 60rem;
  border-top: var(--border);
}

dt,
dd {
  margin: 0;
  padding: var(--space-3) 0;
  border-bottom: var(--border);
}

dt {
  padding-right: var(--space-3);
  color: var(--cobalt-soft);
  font-weight: 700;
}

[data-sources] {
  padding: clamp(1.25rem, 4vw, 2.5rem);
  border: 1px solid var(--cobalt);
  background: var(--ink-soft);
}

[data-sources] h2 {
  font-size: 1.5rem;
}

[data-sources] a {
  display: flex;
  min-height: 48px;
  align-items: center;
  max-width: var(--measure);
  padding-block: 0.4rem;
}

[data-next] {
  display: inline-flex;
  min-height: 48px;
  align-items: center;
  margin-top: var(--space-3);
  padding: 0.55rem 1rem;
  border: 1px solid var(--cobalt);
  text-decoration: none;
}

form {
  max-width: 54rem;
}

fieldset {
  display: grid;
  gap: var(--space-2);
  margin: 0;
  padding: 0;
  border: 0;
}

legend {
  margin-bottom: var(--space-3);
  color: var(--foam-muted);
  font-size: 1rem;
}

fieldset label {
  display: grid;
  grid-template-columns: 2.5rem 1fr;
  gap: var(--space-2);
  min-height: 64px;
  align-items: center;
  padding: var(--space-2) var(--space-3);
  border: var(--border);
  background: var(--ink-raised);
  cursor: pointer;
}

fieldset label:has(input:checked) {
  border-color: var(--cobalt);
  background: var(--ink-soft);
}

input[type="checkbox"] {
  width: 2.5rem;
  height: 2.5rem;
  margin: 0;
  accent-color: var(--cobalt);
}

button {
  min-width: 8rem;
  min-height: 48px;
  margin-top: var(--space-3);
  padding: 0.5rem 1rem;
  border: 1px solid var(--cobalt);
  border-radius: 0;
  background: transparent;
  color: var(--foam);
  font-family: inherit;
  cursor: pointer;
}

button:hover {
  background: var(--cobalt);
  color: #ffffff;
}

footer {
  padding-block: var(--space-5);
  border-top: 2px solid var(--cobalt);
}

footer > p:first-child {
  color: var(--cobalt-soft);
  font-family: ui-monospace, SFMono-Regular, Menlo, Consolas, monospace;
  letter-spacing: 0.08em;
  text-transform: uppercase;
}

footer nav {
  display: grid;
  grid-template-columns: repeat(4, minmax(0, 1fr));
  gap: var(--space-1) var(--space-3);
  margin-block: var(--space-3);
}

footer nav a {
  display: flex;
  min-height: 48px;
  align-items: center;
}

[data-disclaimer] {
  color: var(--foam-muted);
}

.skip-link {
  position: fixed;
  z-index: 10;
  top: 0;
  left: 0;
  min-height: 44px;
  padding: 0.5rem 1rem;
  background: var(--foam);
  color: var(--ink);
  transform: translateY(-120%);
}

.skip-link:focus {
  transform: translateY(0);
}

@media (max-width: 760px) {
  :root {
    --space-5: 2.75rem;
    --space-6: 4.25rem;
  }

  html {
    font-size: 17px;
  }

  [data-grid] > article,
  [data-grid] > section,
  [data-grid="three"] > article {
    grid-column: 1 / -1;
  }

  [data-route] {
    grid-template-columns: 1fr;
    gap: var(--space-2);
  }

  [data-route]::before {
    top: 5%;
    right: auto;
    bottom: 5%;
    left: 50%;
    width: 2px;
    height: auto;
    transform: translateX(-50%);
  }

  [data-route] span {
    width: min(9rem, 70vw);
    min-height: 6.5rem;
    margin-inline: auto;
  }

  [data-network] {
    grid-template-columns: 1fr;
    min-height: 0;
  }

  [data-network]::before,
  [data-network]::after {
    top: 10%;
    bottom: 10%;
    left: 50%;
    width: 2px;
    height: auto;
    transform: none;
  }

  [data-node]:nth-child(2),
  [data-node]:nth-child(3),
  [data-node]:nth-child(5) {
    transform: none;
  }

  [data-bar] {
    grid-template-columns: 1fr auto;
  }

  [data-bar] i {
    grid-column: 1 / -1;
  }

  dl {
    grid-template-columns: 1fr;
  }

  dt {
    padding-bottom: 0;
    border-bottom: 0;
  }

  dd {
    padding-top: var(--space-1);
  }

  footer nav {
    grid-template-columns: repeat(2, minmax(0, 1fr));
  }
}

@media (max-width: 420px) {
  header,
  main,
  footer {
    width: min(100% - 1.25rem, var(--max));
  }

  h1 {
    font-size: clamp(2.25rem, 14vw, 3.35rem);
  }

  [data-network],
  [data-bars] {
    padding: var(--space-3);
  }
}

@media (prefers-reduced-motion: reduce) {
  html {
    scroll-behavior: auto;
  }

  *,
  *::before,
  *::after {
    transition-duration: 0.01ms !important;
    animation-duration: 0.01ms !important;
    animation-iteration-count: 1 !important;
  }
}